The Daily Bulletin

Anjuli Bhandari, a graduate student in forensic science at Buffalo State, will present the literature seminar "Medicinal Applications of Copper Complexes" at 12:30 p.m. Thursday, December 3, in Classroom Building B119. Light refreshments will be served before the seminar. This seminar is supported by the Faculty-Student Association. The abstract of her talk appears as below.

Abstract
Copper is an element vital to human development and daily life. Its vital role was not discovered until 1928, when an experiment performed in mice revealed that mice deficient in copper had a difficult time producing red blood cells. Medicine is an ever-changing field, and copper has now once again made revelations. Copper has been studied in antimicrobial, antiviral, antitumor, antibiotic, and anti-inflammatory settings and has shown significance. A plethora of instrumentation is used to confirm or deny copper’s ability to act as one or more of these agents. Some of the techniques explored in copper’s use are nuclear magnetic resonance, Fourier transform infrared spectroscopy, MTT assay, and carrageenan paw-induced edema assay.

Two papers will be reviewed in which copper is used in different medical applications. The first will review copper as an anti-inflammatory agent. Fenoprofen, a member of the ibuprofen family, will be used as a control. A copper complex synthesized from the fenoprofen salt will be examined against parent fenoprofen as well as against the control, which was the vehicle of carboxymethylcellulose. A carrageenan-induced paw assay will examine the inhibition of inflammation between the three constituents and describe any significant differences. The second paper will review copper as an anti-tumor agent. Four distinct ligands are synthesized, and four copper complexes are then stemmed from these ligands. All four ligands, four complexes, and three known chemotherapeutic drugs (docetaxel, doxorubicin, and monastrol) are compared for their disruption of cancer cell division in two specific breast cancer cell lines: HCC1806 and MCF7.