The Daily Bulletin

Please join the Biology Department and the Great Lakes Center for the seminar "Genetic and Environmental Reprogramming of the Cancer Epigenome," presented by Joyce Ohm, associate professor of oncology with Roswell Park Comprehensive Cancer Institute, on Monday November 14, at 3:00 p.m. in Bulger Communication Center 214.

Dr. Ohm received her Ph.D. in cancer biology from the Vanderbilt University School of Medicine in 2003. Before starting her independent research laboratory, she completed a postdoctoral fellowship in oncology at Johns Hopkins University in Baltimore, Maryland. Dr. Ohm’s research interests include cancer epigenetics, environmental exposures and tumor initiation, stem cell biology and cellular reprogramming, and molecular signatures for lung cancer.

Abstract
Dr. Ohm’s laboratory is actively investigating how both genetic and environmental determinants may reprogram the epigenome and contribute to tumor initiation and progression. She is currently executing research associated with an NIH RO1 grant, which is focused on epigenomic remodeling in stem cells following exposures to environmental toxicants. Other projects that Dr. Ohm’s laboratory is involved in include the examination of epigenetic reprogramming in translocation associated soft-tissue sarcomas with regard to epigenetic remodeling, epigenetic aging, and novel therapeutic strategies including immunotherapy. As Dr. Ohm’s research is analytically intensive, her lab regularly performs –omics level molecular analysis of normal, pre-malignant, and malignant cell populations including RNA-sequencing, ChIP-sequencing, and global methylation analysis, all of which are key elements of her ongoing research. Her long-term goals are to identify novel therapeutic strategies for the treatment of aggressive human cancers based on their molecular profiling.