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Posted: Wednesday, November 13, 2024Chemistry Department Seminar: 'Vitreous Humor Analysis for the Detection of Xenobiotics via Liquid Chromatography-Tandem Mass Spectrometry' - November 14
The Chemistry Department will host a graduate student seminar, “Vitreous Humor Analysis for the Detection of Xenobiotics via Liquid Chromatography-Tandem Mass Spectrometry,” presented by Grace Poleto, a graduate student in the M.S. forensic science program, on Thursday, November 14, during Bengal Pause (12:15–1:30 p.m.) in Science and Mathematics Complex 173.
Abstract
Vitreous humor, the gelatinous fluid that comprises 80 percent of the human eye, plays a crucial role in stabilizing the retina and maintaining biochemical homeostasis. This fluid has proved valuable as an alternative biological matrix for identifying xenobiotics, including illicit drugs, in forensic cases where other biological samples may not be available. Historically, quantifying xenobiotics in vitreous humor presented challenges because of limited analytical methods, but advances in liquid chromatography-tandem mass spectrometry (LC-MS/MS) now allow for the detection of trace non-volatile drugs and their metabolites within complex matrices. In this seminar, Ms. Poleto will present two analyses: one involving benzodiazepines to establish a quantitative extraction method and another examining cocaine and its hydrolysates to compare concentrations with other biological fluids.
Coffee and donuts will be served.
